Try Blokada 5. It sets up a local vpn inside your phone and blocks all the ads and trackers. The application is free and open source. Don’t download it from the play store as it downloads version 6, which requires a subscription (version 5 instead works locally)

https://github.com/blokadaorg/five-android

Enjoy

Not really, but they are alternatives to each other. Bottles can also be configured to run “normal” applications alongside possible games and stuff, while Lutris has more a “gaming” UI vibes (but you can run everything you want on both of them really) and additionally provides some integrations for other emulators. I think it comes down to personal tastes at the end of the day, both of them under the hood use wine/proton and apply settings to it before running the application

Newpipe doesn’t use youtube official API. It does webpage parsing afaik